Ontology highlight
ABSTRACT:
SUBMITTER: Ting YT
PROVIDER: S-EPMC5836122 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Ting Yi Tian YT Petersen Jan J Ramarathinam Sri H SH Scally Stephen W SW Loh Khai L KL Thomas Ranjeny R Suri Anish A Baker Daniel G DG Purcell Anthony W AW Reid Hugh H HH Rossjohn Jamie J
The Journal of biological chemistry 20180109 9
The <i>HLA-DRB1</i> locus is strongly associated with rheumatoid arthritis (RA) susceptibility, whereupon citrullinated self-peptides bind to HLA-DR molecules bearing the shared epitope (SE) amino acid motif. However, the differing propensity for citrullinated/non-citrullinated self-peptides to bind given HLA-DR allomorphs remains unclear. Here, we used a fluorescence polarization assay to determine a hierarchy of binding affinities of 34 self-peptides implicated in RA against three HLA-DRB1 all ...[more]