Dataset Information

Association of IL-6 C-572G Gene Polymorphism with Anti-E Production.

ABSTRACT:

Background

Interleukin 6 (IL-6) is involved in regulation of immunoglobulin production. The aim of this study was to investigate the association between IL-6 single nucleotide polymorphisms (SNPs) in the IL-6 promoter and anti-E in red blood cell (RBC) transfusion recipients.

Methods

50 healthy subjects, 54 patients with RBC alloantibody anti-E (responders), and 45 patients without alloantibody (non-responders) were recruited. All patients were E antigen-negative.

Results

All healthy subjects and patients had GG at -174 position of IL-6 gene. In our healthy subjects, the frequency of the -572 CC genotype was 58%, that of the -572 CG genotype 38%, and that of the -572 GG genotype 4%. The frequency of G allele of -572 SNP in responders was significantly higher than that in non-responders, (31.5 vs. 16.7%; p = 0.020). The frequency of -572 G-positive genotypes (CG and GG) in responders was also significantly higher than that in non-responders, (55.6 vs. 31.1%; p = 0.016). The relative risk of RBC alloimmunization for patients with the -572 G-positive genotype was significantly higher than that of patients with the -572 CC genotype, (1.771 vs. 0.640; p = 0.016).

Conclusion

IL-6 C-572G gene polymorphism is significantly associated with anti-E production, with the allele G as a risk allele.

SUBMITTER: Lin JS

PROVIDER: S-EPMC5836267 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Publications

Association of <i>IL-6</i> C-572G Gene Polymorphism with Anti-E Production.

Lin Jeong-Shi JS Lee Li-Hsuan LH Liu Hsueng-Mei HM Chen Ying-Ju YJ Chiou Tzeon-Jye TJ

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 20170919 1

<h4>Background</h4>Interleukin 6 (IL-6) is involved in regulation of immunoglobulin production. The aim of this study was to investigate the association between IL-6 single nucleotide polymorphisms (SNPs) in the IL-6 promoter and anti-E in red blood cell (RBC) transfusion recipients.<h4>Methods</h4>50 healthy subjects, 54 patients with RBC alloantibody anti-E (responders), and 45 patients without alloantibody (non-responders) were recruited. All patients were E antigen-negative.<h4>Results</h4>A ...[more]

PMID: 29593460

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