Dataset Information

ABO, Rhesus, and Kell Antigens, Alleles, and Haplotypes in West Bengal, India.

ABSTRACT:

Background

Few studies have documented the blood group antigens in the population of eastern India. Frequencies of some common alleles and haplotypes were unknown. We describe phenotype, allele, and haplotype frequencies in the state of West Bengal, India.

Methods

We tested 1,528 blood donors at the Medical College Hospital, Kolkata. The common antigens of the ABO, Rhesus, and Kell blood group systems were determined by standard serologic methods in tubes. Allele and haplotype frequencies were calculated with an iterative method that yielded maximum-likelihood estimates under the assumption of a Hardy-Weinberg equilibrium.

Results

The prevalence of ABO antigens were B (34%), O (32%), A (25%), and AB (9%) with ABO allele frequencies for O = 0.567, A = 0.189, and B = 0.244. The D antigen (RH1) was observed in 96.6% of the blood donors with RH haplotype frequencies, such as for CDe = 0.688809, cde = 0.16983 and CdE = 0.000654. The K antigen (K1) was observed in 12 donors (0.79%) with KEL allele frequencies for K = 0.004 and k = 0.996. Conclusions: For the Bengali population living in the south of West Bengal, we established the frequencies of the major clinically relevant antigens in the ABO, Rhesus, and Kell blood group systems and derived estimates for the underlying ABO and KEL alleles and RH haplotypes. Such blood donor screening will improve the availability of compatible red cell units for transfusion. Our approach using widely available routine methods can readily be applied in other regions, where the sufficient supply of blood typed for the Rh and K antigens is lacking.

SUBMITTER: Basu D

PROVIDER: S-EPMC5836283 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Publications

ABO, Rhesus, and Kell Antigens, Alleles, and Haplotypes in West Bengal, India.

Basu Debapriya D Datta Suvro Sankha SS Montemayor Celina C Bhattacharya Prasun P Mukherjee Krishnendu K Flegel Willy A WA

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 20171020 1

<h4>Background</h4>Few studies have documented the blood group antigens in the population of eastern India. Frequencies of some common alleles and haplotypes were unknown. We describe phenotype, allele, and haplotype frequencies in the state of West Bengal, India.<h4>Methods</h4>We tested 1,528 blood donors at the Medical College Hospital, Kolkata. The common antigens of the ABO, Rhesus, and Kell blood group systems were determined by standard serologic methods in tubes. Allele and haplotype fre ...[more]

PMID: 29593462

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Dataset Information

ABO, Rhesus, and Kell Antigens, Alleles, and Haplotypes in West Bengal, India.

Background

Methods

Results

Publications

ABO, Rhesus, and Kell Antigens, Alleles, and Haplotypes in West Bengal, India.

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