Ontology highlight
ABSTRACT:
SUBMITTER: Bulut-Karslioglu A
PROVIDER: S-EPMC5836508 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Bulut-Karslioglu Aydan A Macrae Trisha A TA Oses-Prieto Juan A JA Covarrubias Sergio S Percharde Michelle M Ku Gregory G Diaz Aaron A McManus Michael T MT Burlingame Alma L AL Ramalho-Santos Miguel M
Cell stem cell 20180301 3
A permissive chromatin environment coupled to hypertranscription drives the rapid proliferation of embryonic stem cells (ESCs) and peri-implantation embryos. We carried out a genome-wide screen to systematically dissect the regulation of the euchromatic state of ESCs. The results revealed that cellular growth pathways, most prominently translation, perpetuate the euchromatic state and hypertranscription of ESCs. Acute inhibition of translation rapidly depletes euchromatic marks in mouse ESCs and ...[more]