Ontology highlight
ABSTRACT:
SUBMITTER: Park SA
PROVIDER: S-EPMC5836560 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Park Seong Ah SA Jeong Mi Suk MS Ha Ki-Tae KT Jang Se Bok SB
BMB reports 20180201 2
Vascular endothelial growth factor and its receptor (VEGF-VEGFR) system play a critical role in the regulation of angiogenesis and lymphangiogenesis in vertebrates. Each of the VEGF has specific receptors, which it activates by binding to the extracellular domain of the receptors, and, thus, regulates the angiogenic balance in the early embryonic and adult stages. However, de-regulation of the VEGF-VEGFR implicates directly in various diseases, particularly cancer. Moreover, tumor growth needs a ...[more]