Ontology highlight
ABSTRACT:
SUBMITTER: Colwell M
PROVIDER: S-EPMC5836973 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Colwell Mathia M Drown Melissa M Showel Kelly K Drown Chelsea C Palowski Amanda A Faulk Christopher C
Epigenetics 20180206 1
Ultraconserved noncoding elements (UCNEs) constitute less than 1 Mb of vertebrate genomes and are impervious to accumulating mutations. About 4000 UCNEs exist in vertebrate genomes, each at least 200 nucleotides in length, sharing greater than 95% sequence identity between human and chicken. Despite extreme sequence conservation over 400 million years of vertebrate evolution, we show both ordered interspecies and within-species interindividual variation in DNA methylation in these regions. Here, ...[more]