Dataset Information

Optimizing waiting duration for renal transplants in the setting of renal malignancy: is 2?years too long to wait?

ABSTRACT:

Background

For potential transplant recipients with a prior history of renal malignancy, no evidence-based recommendations currently exist with regard to waiting duration on dialysis. We aim to improve decision making by evaluating the impact of waiting duration on the outcomes of kidney cancer patients awaiting renal transplantation.

Methods

The United States Renal Data System was used to identify patients with a known cause of end-stage renal disease (ESRD) from 1983 to 2007. Evaluation of overall survival (OS) was performed with Kaplan-Meier estimates and Cox proportional hazards models. Fine-Gray competing risk models were used to assess cancer-specific mortality (CSM) and non-cancer-specific mortality (NCSM).

Results

Of 1?374?175 patients with ESRD, 228?984 (16.7%) received transplantation. Transplant recipients with renal malignancy-associated ESRD (RM-ESRD) had longer waiting durations than those with other known causes of ESRD (2.4 versus 1.3?years; P?ConclusionWe found that CSM was not affected by waiting duration, while NCSM significantly improved with shorter wait times. These findings suggest that the OS of potential transplant recipients with RM-ESRD may be improved by reducing waiting duration.

SUBMITTER: Nguyen KA

PROVIDER: S-EPMC5837216 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Publications

Optimizing waiting duration for renal transplants in the setting of renal malignancy: is 2 years too long to wait?

Nguyen Kevin A KA Syed Jamil S JS Luciano Randy R Shuch Brian B Vourganti Srinivas S

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20171001 10

<h4>Background</h4>For potential transplant recipients with a prior history of renal malignancy, no evidence-based recommendations currently exist with regard to waiting duration on dialysis. We aim to improve decision making by evaluating the impact of waiting duration on the outcomes of kidney cancer patients awaiting renal transplantation.<h4>Methods</h4>The United States Renal Data System was used to identify patients with a known cause of end-stage renal disease (ESRD) from 1983 to 2007. Ev ...[more]

PMID: 28967967

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