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Free-breathing liver fat quantification using a multiecho 3D stack-of-radial technique.


ABSTRACT: PURPOSE:The diagnostic gold standard for nonalcoholic fatty liver disease is an invasive biopsy. Noninvasive Cartesian MRI fat quantification remains limited to a breath-hold (BH). In this work, a novel free-breathing 3D stack-of-radial (FB radial) liver fat quantification technique is developed and evaluated in a preliminary study. METHODS:Phantoms and healthy subjects (n?=?11) were imaged at 3 Tesla. The proton-density fat fraction (PDFF) determined using FB radial (with and without scan acceleration) was compared to BH single-voxel MR spectroscopy (SVS) and BH 3D Cartesian MRI using linear regression (correlation coefficient ? and concordance coefficient ?c ) and Bland-Altman analysis. RESULTS:In phantoms, PDFF showed significant correlation (??>?0.998, ?c ?>?0.995) and absolute mean differences??0.999, ?c ?>?0.998) and absolute mean differences ?0.986, ?c ?>?0.985) and absolute mean differences??0.996, ?c ?>?0.995) and absolute mean differences?

SUBMITTER: Armstrong T 

PROVIDER: S-EPMC5837283 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Free-breathing liver fat quantification using a multiecho 3D stack-of-radial technique.

Armstrong Tess T   Dregely Isabel I   Stemmer Alto A   Han Fei F   Natsuaki Yutaka Y   Sung Kyunghyun K   Wu Holden H HH  

Magnetic resonance in medicine 20170416 1


<h4>Purpose</h4>The diagnostic gold standard for nonalcoholic fatty liver disease is an invasive biopsy. Noninvasive Cartesian MRI fat quantification remains limited to a breath-hold (BH). In this work, a novel free-breathing 3D stack-of-radial (FB radial) liver fat quantification technique is developed and evaluated in a preliminary study.<h4>Methods</h4>Phantoms and healthy subjects (n = 11) were imaged at 3 Tesla. The proton-density fat fraction (PDFF) determined using FB radial (with and wit  ...[more]

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