Dataset Information

Adiposity in relation to age at menarche and other reproductive factors among 300?000 Chinese women: findings from China Kadoorie Biobank study.

ABSTRACT:

Background

Adiposity is increasing rapidly in China but little is known about the relevance to it of women's reproductive factors, which differ inter-generationally and from that in the West. We assess associations of adiposity with life-course reproductive factors in Chinese women.

Methods

In 2004-08, the nationwide China Kadoorie Biobank recruited 303?000 women aged 30-79 (mean 50) years from 10 diverse regions. Multivariable linear regression was used to examine associations of reproductive factors (e.g. age at menarche/first birth/menopause, parity, breastfeeding and reproductive years) with measures of general [e.g. body mass index (BMI)] and central [e.g. waist circumference (WC)] adiposity in adulthood.

Results

Overall, the mean BMI was 23.7 (standard deviation 3.3) kg/m 2 , mean age at menarche was 15 (2) years and nearly all had given birth (99%) and breastfed children (98%). Adiposity was associated inversely with age at menarche and at first birth, with 0.19 and 0.05?kg/m 2 lower BMI and 0.38 and 0.12?cm lower WC per 1-year delay respectively ( P ?ConclusionAmong Chinese women, earlier age at menarche and at first birth, later age at menopause and longer reproductive years were independently associated with increased adiposity late in life.

SUBMITTER: Yang L

PROVIDER: S-EPMC5837303 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Publications

Adiposity in relation to age at menarche and other reproductive factors among 300 000 Chinese women: findings from China Kadoorie Biobank study.

Yang Ling L Li Liming L Millwood Iona Y IY Lewington Sarah S Guo Yu Y Sherliker Paul P Peters Sanne Ae SA Bian Zheng Z Wu Xianping X Yu Min M Liu Huilin H Wang Hongmei H Mao Enke E Chen Junshi J Woodward Mark M Peto Richard R Chen Zhengming Z

International journal of epidemiology 20170401 2

<h4>Background</h4>Adiposity is increasing rapidly in China but little is known about the relevance to it of women's reproductive factors, which differ inter-generationally and from that in the West. We assess associations of adiposity with life-course reproductive factors in Chinese women.<h4>Methods</h4>In 2004-08, the nationwide China Kadoorie Biobank recruited 303 000 women aged 30-79 (mean 50) years from 10 diverse regions. Multivariable linear regression was used to examine associations of ...[more]

PMID: 27524817

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