Antiretroviral therapy use during pregnancy and adverse birth outcomes in South African women.

ABSTRACT:

Background

Studies of antiretroviral therapy (ART) use during pregnancy in HIV-infected women have suggested that ART exposure may be associated with adverse birth outcomes. However, there are few data from sub-Saharan Africa where HIV is most common, and few studies involving the World Health Organization's (WHO's) recommended first-line regimens.

Methods

We enrolled consecutive HIV-infected pregnant women and a comparator cohort of uninfected women at a primary-level antenatal care facility in Cape Town, South Africa. Gestational assessment combined clinical history, examination and ultrasonography; outcomes included preterm (PTD), low birthweight (LBW) and small for gestational age (SGA) deliveries. In analysis we compared birth outcomes between HIV-infected and -uninfect

SUBMITTER: Malaba TR 

PROVIDER: S-EPMC5837407 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature