Ontology highlight
ABSTRACT:
SUBMITTER: Chen N
PROVIDER: S-EPMC5837707 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Chen Nan N Qian Jiaqi J Chen Jianghua J Yu Xueqing X Mei Changlin C Hao Chuanming C Jiang Gengru G Lin Hongli H Zhang Xinzhou X Zuo Li L He Qiang Q Fu Ping P Li Xuemei X Ni Dalvin D Hemmerich Stefan S Liu Cameron C Szczech Lynda L Besarab Anatole A Neff Thomas B TB Peony Yu Kin-Hung KH Valone Frank H FH
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20170801 8
<h4>Background</h4>FG-4592 (roxadustat) is an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor (HIF-PHI) promoting coordinated erythropoiesis through the transcription factor HIF. Two Phase 2 studies were conducted in China to explore the safety and efficacy of FG-4592 (USAN name: roxadustat, CDAN name: ), a HIF-PHI, in patients with anemia of chronic kidney disease (CKD), both patients who were dialysis-dependent (DD) and patients who were not dialysis-dependent (NDD).<h4>Method ...[more]