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Architecture of the human mTORC2 core complex.

ABSTRACT: The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the architecture of human mTORC2 at intermediate resolution, revealing a conserved binding site for accessory proteins on mTOR and explaining the structural basis for the rapamycin insensitivity of the complex.

SUBMITTER: Stuttfeld E

PROVIDER: S-EPMC5837792 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Architecture of the human mTORC2 core complex.

Stuttfeld Edward E Aylett Christopher Hs CH Imseng Stefan S Boehringer Daniel D Scaiola Alain A Sauer Evelyn E Hall Michael N MN Maier Timm T Ban Nenad N

eLife 20180209

The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the architecture of human mTORC2 at intermediate resolution, revealing a conserved binding site for accessory proteins on mTOR and explaining the structural basis for the rapamycin insensitivity of the c ...[more]

PMID: 29424687

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