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Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNA molecules, which function in RNA silencing and post-transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of miRNAs in psoriasis and showed that miRNAs play key roles in psoriasis, including the regulation of hyperproliferation, cytokine and chemokine production in keratinocyte, as well as mediating immune dysfunction in psoriasis. Furthermore, miRNAs, particularly, circulating miRNAs may serve as novel biomarkers for diagnosis, monitoring therapy response and reflecting the disease severity. Thus, targeting specific miRNAs may be used to develop new therapeutic methods for psoriasis.

SUBMITTER: Liu Q

PROVIDER: S-EPMC5837862 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers.

Liu Qing Q Wu Ding-Hong DH Han Ling L Deng Jing-Wen JW Zhou Li L He Rui R Lu Chuan-Jian CJ Mi Qing-Sheng QS

Experimental dermatology 20170301 4

MicroRNAs (miRNAs) are small non-coding RNA molecules, which function in RNA silencing and post-transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of miRNAs in psoriasis and showed that miRNAs play key roles in psoriasis, including the regulation of hyperproliferation, cytokine and chemokine production in keratinocyte, as well as medi ...[more]

PMID: 27783430

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