Ontology highlight
ABSTRACT:
SUBMITTER: Pasquin S
PROVIDER: S-EPMC5838168 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Pasquin Sarah S Chehboun Salma S Dejda Agnieszka A Meliani Yasmine Y Savin Virginia V Warner Gregory J GJ Bosse Roger R Tormo Aurélie A Mayer Gaétan G Sharma Mukut M Sapieha Przemyslaw P Martel Catherine C Gauchat Jean-François JF
Scientific reports 20180305 1
The cytokines CLCF1 and CNTF are ligands for the CNTF receptor and the apolipoprotein E (ApoE) receptor sortilin. Both share structural similarities with the N-terminal domain of ApoE, known to bind CNTF. We therefore evaluated whether ApoE or ApoE-containing lipoproteins interact with CLCF1 and regulate its activity. We observed that CLCF1 forms complexes with the three major isoforms of ApoE in co-immunoprecipitation and proximity assays. FPLC analysis of mouse and human sera mixed with CLCF1 ...[more]