Dataset Information

Single Nucleotide Polymorphism (A870G) of the CCND1 gene: association with colorectal cancer susceptibility.

ABSTRACT:

Aim

The aim of this study is to demonstrate the role of CCND1 gene polymorphism, A870G, in susceptibility to sporadic colorectal cancer in Iranian population.

Background

It has been distinguished that CCND1 gene is one of the main genes in Wnt signaling pathway which involves in generating colorectal cancer. Nonetheless, there is no consistent result in terms of association between the genetic variations of this gene and colorectal cancer risk.

Methods

We designed a case-control study consisting of 100 subjects with colorectal cancer (CRC) and 100 healthy controls to investigate the effect of A870G polymorphism on CRC susceptibility in an Iranian population. Genotype determination was performed by PCR-RFLP method.

Results

The frequency of GG, AG and AA genotypes for cases were 24%, 51% and 25% respectively, while the genotype frequency for controls were 21%, 50% and 29% respectively. It was identified that there is no significant association between A870G polymorphism and risk of CRC, even after adjusting sex, age and smoking status variables (P = 0.777; OR=1.32 95% CI: 0.6-2.93)..

Conclusion

Despite the well-known role of CCND1 gene in cell cycle regulation, our results revealed that A870G polymorphism could not be a potential predisposing risk factor in genetic susceptibility to CRC, at least in the studied population.

SUBMITTER: Montazer Haghighi M

PROVIDER: S-EPMC5838181 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Single Nucleotide Polymorphism (A870G) of the <i>CCND1</i> gene: association with colorectal cancer susceptibility.

Montazer Haghighi Mahdi M Vahedi Mohsen M Nazemolhosseini Mojarad Ehsan E

Gastroenterology and hepatology from bed to bench 20170101 Suppl1

<h4>Aim</h4>The aim of this study is to demonstrate the role of <i>CCND1</i> gene polymorphism, A870G, in susceptibility to sporadic colorectal cancer in Iranian population.<h4>Background</h4>It has been distinguished that <i>CCND1</i> gene is one of the main genes in Wnt signaling pathway which involves in generating colorectal cancer. Nonetheless, there is no consistent result in terms of association between the genetic variations of this gene and colorectal cancer risk.<h4>Methods</h4>We desi ...[more]

PMID: 29511472

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