Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5838802 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Li Hui H Breen Christopher P CP Seo Hyowon H Jamison Timothy F TF Fang Yuan-Qing YQ Bio Matthew M MM
Organic letters 20180212 5
An electrochemically driven, nickel-catalyzed reductive coupling of N-hydroxyphthalimide esters with aryl halides is reported. The reaction proceeds under mild conditions in a divided electrochemical cell and employs a tertiary amine as the reductant. This decarboxylative C(sp<sup>3</sup>)-C(sp<sup>2</sup>) bond-forming transformation exhibits excellent substrate generality and functional group compatibility. An operationally simple continuous-flow version of this transformation using a commerci ...[more]