Ontology highlight
ABSTRACT:
SUBMITTER: Silva CT
PROVIDER: S-EPMC5838853 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Silva Claudia Tamar CT Zorkoltseva Irina V IV Niemeijer Maartje N MN van den Berg Marten E ME Amin Najaf N Demirkan Ayşe A van Leeuwen Elisa E Iglesias Adriana I AI Piñeros-Hernández Laura B LB Restrepo Carlos M CM Kors Jan A JA Kirichenko Anatoly V AV Willemsen Rob R Oostra Ben A BA Stricker Bruno H BH Uitterlinden André G AG Axenovich Tatiana I TI van Duijn Cornelia M CM Isaacs Aaron A
BMC medical genomics 20180305 1
<h4>Background</h4>Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two principal components derived from them.<h4>Methods</h4>The study was conducted among participants from the Erasmus Rucphen Family Study (ERF), a Dutch family-based sample from the southwestern Netherlands. Variance components linkage analyse ...[more]