Basic characteristics of plasma rich in growth factors (PRGF): blood cell components and biological effects.

ABSTRACT: Platelet-rich plasma (PRP) is widely used in regenerative medicine because of its high concentrations of various growth factors and platelets. However, the distribution of blood cell components has not been investigated in either PRP or other PRP derivatives. In this study, we focused on plasma rich in growth factors (PRGF), a PRP derivative, and analyzed the distributions of platelets and white blood cells (WBCs). Peripheral blood samples were collected from healthy volunteers (N = 14) and centrifuged to prepare PRGF and PRP. Blood cells were counted using an automated hematology analyzer. The effects of PRP and PRGF preparations on cell proliferation were determined using human periosteal cells. In the PRGF preparations, both red blood cells and WBCs were almost completely elimina

SUBMITTER: Nishiyama K 

PROVIDER: S-EPMC5839250 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature