Ontology highlight
ABSTRACT:
SUBMITTER: Giampaolo S
PROVIDER: S-EPMC5839390 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Giampaolo Sabrina S Wójcik Gabriela G Klein-Hessling Stefan S Serfling Edgar E Patra Amiya K AK
Oncotarget 20171228 11
The role of NFAT family transcription factors in erythropoiesis is so far unknown, although their involvement has been suggested previously. We have shown recently that <i>Il2</i><sup>-/-</sup> mice develop severe anemia due to defects in KLF1 activity during BM erythropoiesis. Although, KLF1 activity is indispensable for erythropoiesis, the molecular details of <i>Klf1</i> expression have not yet been elucidated. Here we show that an enhanced NFATc1 activity induced by increased integrin-cAMP s ...[more]