Dataset Information
Pd-Catalyzed Acyl C-O Bond Activation for Selective Ring-Opening of ?-Methylene-?-lactones with Amines.
Ontology highlight
ABSTRACT:
SUBMITTER: Malapit CA
PROVIDER: S-EPMC5839468 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Pd-Catalyzed Acyl C-O Bond Activation for Selective Ring-Opening of α-Methylene-β-lactones with Amines.
Organic letters 20170404 8
A Pd-catalyzed ring-opening of β-lactones with various types of amines (primary, secondary, and aryl) to provide β-hydroxy amides with excellent selectivity toward acyl C-O bond cleavage is reported. The utility of this protocol is demonstrated in an asymmetric kinetic resolution providing enantioenriched α-methylene-β-lactones. ...[more]