Ontology highlight
ABSTRACT:
SUBMITTER: Yanagisawa S
PROVIDER: S-EPMC5839577 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Yanagisawa Satoru S Baker Jonathan R JR Vuppusetty Chaitanya C Koga Takeshi T Colley Thomas T Fenwick Peter P Donnelly Louise E LE Barnes Peter J PJ Ito Kazuhiro K
PloS one 20180306 3
SIRT1 (silent information regulator 2 homolog 1) is a crucial cellular survival protein especially in oxidative stress environments, and has been thought to locate within the nuclei, but also known to shuttle between cytoplasm and nuclei in some cell types. Here, we show for the first time the dynamics of SIRT1 in the presence of single or concurrent cigarette smoke extract (CSE) exposure in human bronchial epithelial cells (HBEC). In BEAS-2B HBEC or primary HBEC, SIRT1 was localized predominant ...[more]