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Deficiency in T follicular regulatory cells promotes autoimmunity.

ABSTRACT: T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6^fl/flFoxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses. These mice exhibited enhanced immunity to influenza virus; moreover, Bcl6^fl/flFoxp3Cre/Cre mice developed late-onset spontaneous autoimmune diseases, affecting the salivary glands with lymphocyte infiltration and antibody deposition. In a mouse experimental Sjögren's syndrome model, ablation of Bcl6 in T reg cells greatly enhanced disease development. Conversely, Bcl6^fl/flCd4Cre mice were protected in the model. Thus, our study indicates that Tfr cells control autoimmune diseases and can be targeted in infectious and autoimmune disease.

SUBMITTER: Fu W

PROVIDER: S-EPMC5839755 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Deficiency in T follicular regulatory cells promotes autoimmunity.

Fu Weiwei W Liu Xindong X Lin Xiang X Feng Han H Sun Lin L Li Shuran S Chen Hairong H Tang Hong H Lu Liwei L Jin Wei W Dong Chen C

The Journal of experimental medicine 20180129 3

T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6fl/flFoxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses. These mice exhibited enhanced immunity to influenza virus; moreover, Bcl6fl/flFoxp3Cre/Cre mice developed late-on ...[more]

PMID: 29378778

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T follicular helper and T follicular regulatory cells have different TCR specificity.

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