Ontology highlight
ABSTRACT:
SUBMITTER: Shee K
PROVIDER: S-EPMC5839765 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Shee Kevin K Yang Wei W Hinds John W JW Hampsch Riley A RA Varn Frederick S FS Traphagen Nicole A NA Patel Kishan K Cheng Chao C Jenkins Nicole P NP Kettenbach Arminja N AN Demidenko Eugene E Owens Philip P Faber Anthony C AC Golub Todd R TR Straussman Ravid R Miller Todd W TW
The Journal of experimental medicine 20180207 3
Drug resistance to approved systemic therapies in estrogen receptor-positive (ER+) breast cancer remains common. We hypothesized that factors present in the human tumor microenvironment (TME) drive drug resistance. Screening of a library of recombinant secreted microenvironmental proteins revealed fibroblast growth factor 2 (FGF2) as a potent mediator of resistance to anti-estrogens, mTORC1 inhibition, and phosphatidylinositol 3-kinase inhibition in ER+ breast cancer. Phosphoproteomic analyses i ...[more]