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Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis.


ABSTRACT: One of the most common head and neck cancers is laryngeal squamous cell carcinoma (LSCC). LSCC exhibits high mortality rates and has a poor prognosis. The molecular mechanisms leading to the development and progression of LSCC are not entirely clear despite genetic and therapeutic advances and increased survival rates. In this study, a total of 116 differentially expressed genes (DEGs), including 11 upregulated genes and 105 downregulated genes, were screened from LSCC samples and compared with adjacent noncancerous. Statistically significant differences (log 2-fold difference > 0.5 and adjusted P-value?

SUBMITTER: Yang CW 

PROVIDER: S-EPMC5839854 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis.

Yang Chun-Wei CW   Wang Shu-Fang SF   Yang Xiang-Li XL   Wang Lin L   Niu Lin L   Liu Ji-Xiang JX  

Medicine 20180201 7


One of the most common head and neck cancers is laryngeal squamous cell carcinoma (LSCC). LSCC exhibits high mortality rates and has a poor prognosis. The molecular mechanisms leading to the development and progression of LSCC are not entirely clear despite genetic and therapeutic advances and increased survival rates. In this study, a total of 116 differentially expressed genes (DEGs), including 11 upregulated genes and 105 downregulated genes, were screened from LSCC samples and compared with  ...[more]

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