Ontology highlight
ABSTRACT:
SUBMITTER: Correnti CE
PROVIDER: S-EPMC5840021 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Correnti Colin E CE Gewe Mesfin M MM Mehlin Christopher C Bandaranayake Ashok D AD Johnsen William A WA Rupert Peter B PB Brusniak Mi-Youn MY Clarke Midori M Burke Skyler E SE De Van Der Schueren Willem W Pilat Kristina K Turnbaugh Shanon M SM May Damon D Watson Alex A Chan Man Kid MK Bahl Christopher D CD Olson James M JM Strong Roland K RK
Nature structural & molecular biology 20180226 3
Peptides folded through interwoven disulfides display extreme biochemical properties and unique medicinal potential. However, their exploitation has been hampered by the limited amounts isolatable from natural sources and the expense of chemical synthesis. We developed reliable biological methods for high-throughput expression, screening and large-scale production of these peptides: 46 were successfully produced in multimilligram quantities, and >600 more were deemed expressible through stringen ...[more]