Cerebral blood flow predicts differential neurotransmitter activity.
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ABSTRACT:
SUBMITTER: Dukart J
PROVIDER: S-EPMC5840131 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Cerebral blood flow predicts differential neurotransmitter activity.
Dukart Juergen J Holiga Štefan Š Chatham Christopher C Hawkins Peter P Forsyth Anna A McMillan Rebecca R Myers Jim J Lingford-Hughes Anne R AR Nutt David J DJ Merlo-Pich Emilio E Risterucci Celine C Boak Lauren L Umbricht Daniel D Schobel Scott S Liu Thomas T Mehta Mitul A MA Zelaya Fernando O FO Williams Steve C SC Brown Gregory G Paulus Martin M Honey Garry D GD Muthukumaraswamy Suresh S Hipp Joerg J Bertolino Alessandro A Sambataro Fabio F
Scientific reports 20180306 1
Application of metabolic magnetic resonance imaging measures such as cerebral blood flow in translational medicine is limited by the unknown link of observed alterations to specific neurophysiological processes. In particular, the sensitivity of cerebral blood flow to activity changes in specific neurotransmitter systems remains unclear. We address this question by probing cerebral blood flow in healthy volunteers using seven established drugs with known dopaminergic, serotonergic, glutamatergic ...[more]
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