Ontology highlight
ABSTRACT:
SUBMITTER: Han Y
PROVIDER: S-EPMC5840155 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Han Ying Y Zheng Yangmin Y Zhang Jingpu J Hu Changqin C
Frontiers in pharmacology 20180302
Most third- and fourth-generation cephalosporins, such as cefotaxime, cefmenoxime, cefepime, and cefpirome, contain an aminothiazoyl ring at the C-7 position. Drug impurity, which may be produced either during synthesis or upon degradation, can induce adverse effects. Various reports have indicated that neurotoxicity is a side effect of cephalosporin. In this study, we developed methods for assessing the free-swimming activities and behaviors in zebrafish larvae in response to continuous darknes ...[more]