Involvement of Cellular Prion Protein in ?-Synuclein Transport in Neurons.
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ABSTRACT:
SUBMITTER: Urrea L
PROVIDER: S-EPMC5840251 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons.
Urrea Laura L Segura-Feliu Miriam M Masuda-Suzukake Masami M Hervera Arnau A Pedraz Lucas L García Aznar José Manuel JM Vila Miquel M Samitier Josep J Torrents Eduard E Ferrer Isidro I Gavín Rosalina R Hagesawa Masato M Del Río José Antonio JA
Molecular neurobiology 20170222 3
The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Results demonstrate that Prnp expression is not mandatory for α-synuclein spreading. However, although the pathological spreading of α-synuclein can take place in the absence of Prnp, α-synuclein expande ...[more]
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