Ontology highlight
ABSTRACT:
SUBMITTER: Lai D
PROVIDER: S-EPMC5840374 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Lai Dengming D Tang Jing J Chen Linsong L Fan Erica K EK Scott Melanie J MJ Li Yuehua Y Billiar Timothy R TR Wilson Mark A MA Fang Xiangming X Shu Qiang Q Fan Jie J
Cell death & disease 20180306 3
Group 2 innate lymphoid cells (ILC2) are one of three subgroups of innate lymphoid cells (ILC1, ILC2, and ILC3), and the major ILC population detected in the lungs. The function of ILC2 in the regulation of lung inflammation remains unclear. In the current study, we explored an important role of ILC2 in protecting lung endothelial cell (EC) from pyroptosis in sepsis-induced acute lung inflammation and the underlying mechanism. Using a cecal ligation and puncture (CLP) mouse sepsis model, we demo ...[more]