Dataset Information

Long-term study of the association of adipokines and glucose variability with diabetic complications.

ABSTRACT:

Background/aims

Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications.

Methods

A total of 161 diabetic individuals were followed-up from 2002 to 2013. Circulating plasma levels of adiponectin, glypican-4, irisin, visfatin, and visit-to-visit glucose variability were measured in diabetic patients. Associations among adipokines and variable metabolic parameters and microvascular, and macrovascular complications were evaluated.

Results

Plasma adiponectin and glypican-4 levels were significantly increased in patients with renal insufficiency. These adipokines were negatively associated with estimated glomerular filtration rate and positively associated with urinary albumin excretion. The relative risk of renal progression to dialysis increased independently with increasing level of adiponectin. Glypican-4 and visfatin were not predictive of any microvascular or macrovascular complications. Glucose variability increased the risk of diabetic nephropathy and cerebrovascular complications.

Conclusions

Adiponectin and glypican-4 were associated with renal function and might be able to predict renal progression. Glucose variability was a predictable factor for diabetic nephropathy and cerebrovascular complications.

SUBMITTER: Cha JJ

PROVIDER: S-EPMC5840591 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Publications

Long-term study of the association of adipokines and glucose variability with diabetic complications.

Cha Jin Joo JJ Min Hye Sook HS Kim Kitae K Lee Mi Jin MJ Lee Mi Hwa MH Kim Jung Eun JE Song Hye Kyoung HK Cha Dae Ryong DR Kang Young Sun YS

The Korean journal of internal medicine 20161104 2

<h4>Background/aims</h4>Recent studies have suggested an important role of adipokines in the development of insulin resistance and diabetes mellitus. The clinical relevance of adipokines on long-term outcomes in patients with diabetes and chronic kidney disease is uncertain. The purpose of this study was to identify a predictable factor in patients with long-term diabetic complications.<h4>Methods</h4>A total of 161 diabetic individuals were followed-up from 2002 to 2013. Circulating plasma leve ...[more]

PMID: 27809453

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Dataset Information

Long-term study of the association of adipokines and glucose variability with diabetic complications.

Background/aims

Methods

Results

Conclusions

Publications

Long-term study of the association of adipokines and glucose variability with diabetic complications.

Similar Datasets

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