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SABRE-Relay: A Versatile Route to Hyperpolarization.


ABSTRACT: Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H2) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine, and pyrazine). The substrate then reacts reversibly with [Pt(OTf)2(bis-diphenylphosphinopropane)] by displacing OTf- to form [Pt(OTf)(sub)(bis-diphenylphosphinopropane)]OTf. The 31P NMR signals of these metal complexes prove to be enhanced when the substrate possesses an accessible singlet state or long-lived Zeeman polarization. In the case of pyrazine, the corresponding 31P signal was 105 ± 8 times larger than expected, which equated to an 8 h reduction in total scan time for an equivalent signal-to-noise ratio under normal acquisition conditions. Hence, p-H2 derived spin order is successfully relayed into a second metal complex via a suitable polarization carrier (sub). When fully developed, we expect this route involving a second catalyst to successfully hyperpolarize many classes of substrates that are not amenable to the original SABRE method.

SUBMITTER: Roy SS 

PROVIDER: S-EPMC5840861 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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SABRE-Relay: A Versatile Route to Hyperpolarization.

Roy Soumya S SS   Appleby Kate M KM   Fear Elizabeth J EJ   Duckett Simon B SB  

The journal of physical chemistry letters 20180219 5


Signal Amplification by Reversible Exchange (SABRE) is used to switch on the latent singlet spin order of para-hydrogen (p-H<sub>2</sub>) so that it can hyperpolarize a substrate (sub = nicotinamide, nicotinate, niacin, pyrimidine, and pyrazine). The substrate then reacts reversibly with [Pt(OTf)<sub>2</sub>(bis-diphenylphosphinopropane)] by displacing OTf<sup>-</sup> to form [Pt(OTf)(sub)(bis-diphenylphosphinopropane)]OTf. The <sup>31</sup>P NMR signals of these metal complexes prove to be enha  ...[more]

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