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Subarachnoid blood acutely induces spreading depolarizations and early cortical infarction.


ABSTRACT: See Ghoshal and Claassen (doi:10.1093/brain/awx226) for a scientific commentary on this article.

SUBMITTER: Hartings JA 

PROVIDER: S-EPMC5841026 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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See Ghoshal and Claassen (doi:10.1093/brain/awx226) for a scientific commentary on this article. Early cortical infarcts are common in poor-grade patients after aneurysmal subarachnoid haemorrhage. There are no animal models of these lesions and mechanisms are unknown, although mass cortical spreading depolarizations are hypothesized as a requisite mechanism and clinical marker of infarct development. Here we studied acute sequelae of subarachnoid haemorrhage in the gyrencephalic brain of propo  ...[more]

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