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Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017.


ABSTRACT: The 2017 Hong Kong influenza A(H3N2) summer season was unexpectedly severe. However, antigenic characterization of the 2017 circulating A(H3N2) viruses using ferret antisera did not show significant antigenic drift. We analyzed the hemagglutinin amino acid sequences of A(H3N2) virus circulating in Hong Kong in 2017, and found that viruses with hemagglutinin N121K substitution, which was rare before 2017, emerged rapidly and dominated in 2017 (52.4% of A[H3N2] virus in 2017 contains N121K substitution). Microneutralization assay using archived human sera collected from mid-2017 showed that the geometric mean microneutralization titer was 3.6-fold lower against a 2017 cell culture-grown circulating A(H3N2)-N121K virus (3391/2017 virus) than that against the cell culture-grown 2016-2017 A(H3N2) seasonal influenza vaccine-like vaccine virus (4801/2014 virus) (13.4 vs 41.8, P?

SUBMITTER: Zhu H 

PROVIDER: S-EPMC5841213 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017.

Zhu Houshun H   Lee Andrew C Y ACY   Li Can C   Mak Winger W N WWN   Chen Yetta Y YY   Chan Kwok-Hung KH   Zhang Anna J X AJX   Fung Wai-Fong WF   Zhang Rui-Qi RQ   Fung Yim-Fong YF   Poon Rosana W S RWS   Lam Joy-Yan JY   Tam Sidney S   Hung Ivan F N IFN   Chen Honglin H   Yuen Kwok-Yung KY   To Kelvin K W KKW  

Emerging microbes & infections 20180306 1


The 2017 Hong Kong influenza A(H3N2) summer season was unexpectedly severe. However, antigenic characterization of the 2017 circulating A(H3N2) viruses using ferret antisera did not show significant antigenic drift. We analyzed the hemagglutinin amino acid sequences of A(H3N2) virus circulating in Hong Kong in 2017, and found that viruses with hemagglutinin N121K substitution, which was rare before 2017, emerged rapidly and dominated in 2017 (52.4% of A[H3N2] virus in 2017 contains N121K substit  ...[more]

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