Ontology highlight
ABSTRACT:
SUBMITTER: Ferla S
PROVIDER: S-EPMC5841303 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Ferla Salvatore S Netzler Natalie E NE Ferla Sebastiano S Veronese Sofia S Tuipulotu Daniel Enosi DE Guccione Salvatore S Brancale Andrea A White Peter A PA Bassetto Marcella M
Scientific reports 20180307 1
Human norovirus causes approximately 219,000 deaths annually, yet there are currently no antivirals available. A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the norovirus RNA-dependent RNA polymerase (RdRp). Selected compounds (n = 62) were examined for inhibition of norovirus RdRp activity using an in vitro transcription assay. Eight candidates demonstrated RdRp inhibition (>25% inhibition at 10 µM), which wa ...[more]