Glutamine Codon Usage and polyQ Evolution in Primates Depend on the Q Stretch Length.
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ABSTRACT:
SUBMITTER: Mier P
PROVIDER: S-EPMC5841385 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Glutamine Codon Usage and polyQ Evolution in Primates Depend on the Q Stretch Length.
Mier Pablo P Andrade-Navarro Miguel A MA
Genome biology and evolution 20180301 3
Amino acid usage in a proteome depends mostly on its taxonomy, as it does the codon usage in transcriptomes. Here, we explore the level of variation in the codon usage of a specific amino acid, glutamine, in relation to the number of consecutive glutamine residues. We show that CAG triplets are consistently more abundant in short glutamine homorepeats (polyQ, four to eight residues) than in shorter glutamine stretches (one to three residues), leading to the evolutionary growth of the repeat regi ...[more]
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