Ontology highlight
ABSTRACT:
SUBMITTER: Aoki H
PROVIDER: S-EPMC5841866 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Aoki Hitomi H Hara Akira A Kunisada Takahiro T
JCI insight 20171005 19
Kit receptor tyrosine kinase is highly expressed in the developing mammalian brain, yet little is known about its contribution to neural cell development and function. Here we introduced a brain-specific conditional Kit loss-of-function mutation in mice and observed severe hypoplasia of the central nervous system. This was accompanied by an increase in apoptotic cell death in the early embryonic brain and the gradual loss of the self-renewal capacity of neuronal stem/precursor cells. A single co ...[more]