Ontology highlight
ABSTRACT:
SUBMITTER: Zhou MN
PROVIDER: S-EPMC5842139 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zhou Matthew N MN Delaveris Corleone S CS Kramer Jessica R JR Kenkel Justin A JA Engleman Edgar G EG Bertozzi Carolyn R CR
Angewandte Chemie (International ed. in English) 20180221 12
The C-type lectins dectin-1 and dectin-2 contribute to innate immunity against microbial pathogens by recognizing their foreign glycan structures. These receptors are promising targets for vaccine development and cancer immunotherapy. However, currently available agonists are heterogeneous glycoconjugates and polysaccharides from natural sources. Herein, we designed and synthesized the first chemically defined ligands for dectin-1 and dectin-2. They comprised glycopolypeptides bearing mono-, di- ...[more]