Ontology highlight
ABSTRACT:
SUBMITTER: Neudecker V
PROVIDER: S-EPMC5842431 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Neudecker Viola V Brodsky Kelley S KS Clambey Eric T ET Schmidt Eric P EP Packard Thomas A TA Davenport Bennett B Standiford Theodore J TJ Weng Tingting T Fletcher Ashley A AA Barthel Lea L Masterson Joanne C JC Furuta Glenn T GT Cai Chunyan C Blackburn Michael R MR Ginde Adit A AA Graner Michael W MW Janssen William J WJ Zemans Rachel L RL Evans Christopher M CM Burnham Ellen L EL Homann Dirk D Moss Marc M Kreth Simone S Zacharowski Kai K Henson Peter M PM Eltzschig Holger K HK
Science translational medicine 20170901 408
Intercellular transfer of microRNAs can mediate communication between critical effector cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial cells could alter mucosal gene expression during acute lung injury. Pulmonary-epithelial microRNA profiling during coculture of alveolar epithelial cells with polymorphonuclear neutrophils (PMNs) revealed a selective increase in lung epithelial cell expression of microRNA-223 (<i>miR-223</i>). Analysis of PMN-derived ...[more]