Modified aging of elite athletes revealed by analysis of epigenetic age markers.
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ABSTRACT:
SUBMITTER: Spolnicka M
PROVIDER: S-EPMC5842850 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Modified aging of elite athletes revealed by analysis of epigenetic age markers.
Spólnicka Magdalena M Pośpiech Ewelina E Adamczyk Jakub Grzegorz JG Freire-Aradas Ana A Pepłońska Beata B Zbieć-Piekarska Renata R Makowska Żanetta Ż Pięta Anna A Lareu Maria Victoria MV Phillips Christopher C Płoski Rafał R Żekanowski Cezary C Branicki Wojciech W
Aging 20180201 2
Recent progress in epigenomics has led to the development of prediction systems that enable accurate age estimation from DNA methylation data. Our objective was to track responses to intense physical exercise of individual age-correlated DNA methylation markers and to infer their potential impact on the aging processes. The study showed accelerated DNA hypermethylation for two CpG sites in <i>TRIM59</i> and <i>KLF14</i>. Both markers predicted the investigated elite athletes to be several years ...[more]
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