Ontology highlight
ABSTRACT:
SUBMITTER: Dolezelova E
PROVIDER: S-EPMC5843355 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Doleželová Eva E Terán David D Gahura Ondřej O Kotrbová Zuzana Z Procházková Michaela M Keough Dianne D Špaček Petr P Hocková Dana D Guddat Luke L Zíková Alena A
PLoS neglected tropical diseases 20180226 2
Due to toxicity and compliance issues and the emergence of resistance to current medications new drugs for the treatment of Human African Trypanosomiasis are needed. A potential approach to developing novel anti-trypanosomal drugs is by inhibition of the 6-oxopurine salvage pathways which synthesise the nucleoside monophosphates required for DNA/RNA production. This is in view of the fact that trypanosomes lack the machinery for de novo synthesis of the purine ring. To provide validation for thi ...[more]