Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy.
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ABSTRACT:
SUBMITTER: Burke MA
PROVIDER: S-EPMC5843375 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy.
Burke Michael A MA Cook Stuart A SA Seidman Jonathan G JG Seidman Christine E CE
Journal of the American College of Cardiology 20161201 25
Over the last quarter-century, there has been tremendous progress in genetics research that has defined molecular causes for cardiomyopathies. More than a thousand mutations have been identified in many genes with varying ontologies, therein indicating the diverse molecules and pathways that cause hypertrophic, dilated, restrictive, and arrhythmogenic cardiomyopathies. Translation of this research to the clinic via genetic testing can precisely group affected patients according to molecular etio ...[more]
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