Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice.
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ABSTRACT:
SUBMITTER: Hwang CH
PROVIDER: S-EPMC5843465 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Role of bone morphogenetic proteins on cochlear hair cell formation: analyses of Noggin and Bmp2 mutant mice.
Hwang Chan Ho CH Guo Dayong D Harris Marie A MA Howard Omar O Mishina Yuji Y Gan Lin L Harris Stephen E SE Wu Doris K DK
Developmental dynamics : an official publication of the American Association of Anatomists 20100201 2
The mammalian organ of Corti of the inner ear is a highly sophisticated sensory end organ responsible for detecting sound. Noggin is a secreted glycoprotein, which antagonizes bone morphogenetic proteins 2 and 4 (Bmp2 and Bmp4). The lack of this antagonist causes increased rows of inner and outer hair cells in the organ of Corti. In mice, Bmp2 is expressed transiently in nascent cochlear hair cells. To investigate whether Noggin normally modulates the levels of Bmp2 for hair cell formation, we d ...[more]
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