Ontology highlight
ABSTRACT:
SUBMITTER: Lenoir M
PROVIDER: S-EPMC5843628 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Lenoir Marc M Ustunel Cansel C Rajesh Sandya S Kaur Jaswant J Moreau Dimitri D Gruenberg Jean J Overduin Michael M
Nature communications 20180308 1
Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate retromer-mediated segregation of cargoes to the trans-Golgi network (TGN). Here we report the solution structure of full length human SNX3, and show that PI3P recognition is accompanied by bilayer insertion of a proximal loop in its extended Phox homology ( ...[more]