Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
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ABSTRACT:
SUBMITTER: Zhao W
PROVIDER: S-EPMC5844224 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
Zhao Wei W Rasheed Asif A Tikkanen Emmi E Lee Jung-Jin JJ Butterworth Adam S AS Howson Joanna M M JMM Assimes Themistocles L TL Chowdhury Rajiv R Orho-Melander Marju M Damrauer Scott S Small Aeron A Asma Senay S Imamura Minako M Yamauch Toshimasa T Chambers John C JC Chen Peng P Sapkota Bishwa R BR Shah Nabi N Jabeen Sehrish S Surendran Praveen P Lu Yingchang Y Zhang Weihua W Imran Atif A Abbas Shahid S Majeed Faisal F Trindade Kevin K Qamar Nadeem N Mallick Nadeem Hayyat NH Yaqoob Zia Z Saghir Tahir T Rizvi Syed Nadeem Hasan SNH Memon Anis A Rasheed Syed Zahed SZ Memon Fazal-Ur-Rehman FU Mehmood Khalid K Ahmed Naveeduddin N Qureshi Irshad Hussain IH Tanveer-Us-Salam Iqbal Wasim W Malik Uzma U Mehra Narinder N Kuo Jane Z JZ Sheu Wayne H-H WH Guo Xiuqing X Hsiung Chao A CA Juang Jyh-Ming J JJ Taylor Kent D KD Hung Yi-Jen YJ Lee Wen-Jane WJ Quertermous Thomas T Lee I-Te IT Hsu Chih-Cheng CC Bottinger Erwin P EP Ralhan Sarju S Teo Yik Ying YY Wang Tzung-Dau TD Alam Dewan S DS Di Angelantonio Emanuele E Epstein Steve S Nielsen Sune F SF Nordestgaard Børge G BG Tybjaerg-Hansen Anne A Young Robin R Benn Marianne M Frikke-Schmidt Ruth R Kamstrup Pia R PR Jukema J Wouter JW Sattar Naveed N Smit Roelof R Chung Ren-Hua RH Liang Kae-Woei KW Anand Sonia S Sanghera Dharambir K DK Ripatti Samuli S Loos Ruth J F RJF Kooner Jaspal S JS Tai E Shyong ES Rotter Jerome I JI Chen Yii-Der Ida YI Frossard Philippe P Maeda Shiro S Kadowaki Takashi T Reilly Muredach M Pare Guillaume G Melander Olle O Salomaa Veikko V Rader Daniel J DJ Danesh John J Voight Benjamin F BF Saleheen Danish D
Nature genetics 20170904 10
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. J ...[more]
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