Global analysis of A-to-I RNA editing reveals association with common disease variants.
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ABSTRACT:
SUBMITTER: Franzen O
PROVIDER: S-EPMC5844249 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Global analysis of A-to-I RNA editing reveals association with common disease variants.
Franzén Oscar O Ermel Raili R Sukhavasi Katyayani K Jain Rajeev R Jain Anamika A Betsholtz Christer C Giannarelli Chiara C Kovacic Jason C JC Ruusalepp Arno A Skogsberg Josefin J Hao Ke K Schadt Eric E EE Björkegren Johan L M JLM
PeerJ 20180306
RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6 million A-to-I edits were identified in 62% of all protein-coding transcripts. mRNA recoding was extremely rare; only 11 novel recoding sites were uncovered. Thirty single nucleotide polymorphisms from genome-wide association studies were associated ...[more]
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