Ontology highlight
ABSTRACT:
SUBMITTER: Nordquist SK
PROVIDER: S-EPMC5844316 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nordquist Sarah K SK Smith Sofia R SR Pierce Jonathan T JT
G3 (Bethesda, Md.) 20180302 3
Individuals with Down syndrome have neurological and muscle impairments due to an additional copy of the human 21st chromosome (HSA21). Only a few of ∼200 HSA21 genes encoding proteins have been linked to specific Down syndrome phenotypes, while the remainder are understudied. To identify poorly characterized HSA21 genes required for nervous system function, we studied behavioral phenotypes caused by loss-of-function mutations in conserved HSA21 orthologs in the nematode <i>Caenorhabditis elegan ...[more]