Ontology highlight
ABSTRACT:
SUBMITTER: De Luca R
PROVIDER: S-EPMC5844457 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
De Luca Roberto R Soltermann Alex A Pretto Francesca F Pemberton-Ross Catherine C Pellegrini Giovanni G Wulhfard Sarah S Neri Dario D
Molecular cancer therapeutics 20170717 11
A novel biopharmaceutical, consisting of the F8 mAb (specific to a splice isoform of fibronectin) simultaneously fused to both TNF and IL2, was found to react with the majority of solid tumors and hematologic malignancies in mouse and man, but not with healthy adult tissues. The product selectively localized to neoplastic lesions <i>in vivo</i>, as evidenced by quantitative biodistribution studies using radioiodinated protein preparations. When the potency of the cytokine payloads was matched by ...[more]