Ontology highlight
ABSTRACT:
SUBMITTER: Garabedian A
PROVIDER: S-EPMC5844780 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Garabedian Alyssa A Benigni Paolo P Ramirez Cesar E CE Baker Erin S ES Liu Tao T Smith Richard D RD Fernandez-Lima Francisco F
Journal of the American Society for Mass Spectrometry 20170909 5
In the present work, the potential of trapped ion mobility spectrometry coupled to TOF mass spectrometry (TIMS-TOF MS) for discovery and targeted monitoring of peptide biomarkers from human-in-mouse xenograft tumor tissue was evaluated. In particular, a TIMS-MS workflow was developed for the detection and quantification of peptide biomarkers using internal heavy analogs, taking advantage of the high mobility resolution (R = 150-250) prior to mass analysis. Five peptide biomarkers were separated, ...[more]