Ontology highlight
ABSTRACT:
SUBMITTER: Melamed P
PROVIDER: S-EPMC5844914 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Melamed Philippa P Yosefzon Yahav Y David Cfir C Tsukerman Anna A Pnueli Lilach L
Frontiers in cell and developmental biology 20180305
Discovery of the ten-eleven translocation 1 (TET) methylcytosine dioxygenase family of enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the epigenetic modifications of DNA. Initially described as catalyzing the oxidation of methyl cytosine (5mC) to hydroxymethyl cytosine (5hmC), it is now clear that these enzymes can also catalyze additional reactions leading to active DNA demethylation. The association of TET enzymes, as well as the 5hmC, with active regulatory regio ...[more]