Ontology highlight
ABSTRACT:
SUBMITTER: Cheron G
PROVIDER: S-EPMC5845018 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cheron Guy G Márquez-Ruiz Javier J Cheron Julian J Prigogine Cynthia C Ammann Claudia C Lukowski Robert R Ruth Peter P Dan Bernard B
Scientific reports 20180309 1
Purkinje cells (PC) control deep cerebellar nuclei (DCN), which in turn inhibit inferior olive nucleus, closing a positive feedback loop via climbing fibers. PC highly express potassium BK channels but their contribution to the olivo-cerebellar loop is not clear. Using multiple-unit recordings in alert mice we found in that selective deletion of BK channels in PC induces a decrease in their simple spike firing with a beta-range bursting pattern and fast intraburst frequency (~200 Hz). To determi ...[more]